Intralymphatic histiocytosis comprises M2 macrophages in superficial dermal lymphatics with or without smooth muscles.
Identifieur interne : 000F41 ( Main/Exploration ); précédent : 000F40; suivant : 000F42Intralymphatic histiocytosis comprises M2 macrophages in superficial dermal lymphatics with or without smooth muscles.
Auteurs : Noriki Fujimoto [Japon] ; Gen Nakanishi [Japon] ; Toshiaki Manabe [Japon] ; Taku Fujimura [Japon] ; Toshihiro Tanaka [Japon]Source :
- Journal of cutaneous pathology [ 1600-0560 ] ; 2016.
Descripteurs français
- KwdFr :
- Derme (anatomopathologie), Derme (métabolisme), Femelle, Histiocytose (anatomopathologie), Histiocytose (métabolisme), Humains, Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Macrophages (anatomopathologie), Macrophages (métabolisme), Maladie chronique, Muscles lisses (anatomopathologie), Muscles lisses (métabolisme), Sujet âgé, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Derme, Histiocytose, Lymphoedème, Macrophages, Muscles lisses, Vaisseaux lymphatiques.
- métabolisme : Derme, Histiocytose, Lymphoedème, Macrophages, Muscles lisses, Vaisseaux lymphatiques.
- Femelle, Humains, Maladie chronique, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Chronic Disease, Dermis (metabolism), Dermis (pathology), Female, Histiocytosis (metabolism), Histiocytosis (pathology), Humans, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (metabolism), Lymphedema (pathology), Macrophages (metabolism), Macrophages (pathology), Muscle, Smooth (metabolism), Muscle, Smooth (pathology).
- MESH :
- metabolism : Dermis, Histiocytosis, Lymphatic Vessels, Lymphedema, Macrophages, Muscle, Smooth.
- pathology : Dermis, Histiocytosis, Lymphatic Vessels, Lymphedema, Macrophages, Muscle, Smooth.
- Aged, Chronic Disease, Female, Humans.
Abstract
Intralymphatic histiocytosis represents a rare reactive disorder, which is characterized by the accumulation of macrophages within lymphatic vessels and observed predominantly in upper extremities. The infiltration and preferential M2 differentiation of macrophage are observed in chronic lymphedema, and lymphedema is considered a causative factor of intralymphatic histiocytosis. However, what causes accumulation of histiocytes in the lymphatic vessels remains unclear, and investigation regarding the characteristics of the macrophages has not been evaluated. We present a case of intralymphatic histiocytosis, in which immunohistochemical staining for both macrophages and lymphatic vessels was performed to evaluate the nature of macrophages within lymphatic vessels and to determine the causative factor. Aggregated macrophages were shown to be M2 macrophages positive for CD68, CD163 and CD206 but negative for inducible nitric oxide synthase. Thick lymphatic vessels positive for D2-40 and α-SMA in the superficial dermis were observed. We speculate that chronic lymphedema leads to hypertrophy of lymphatic vessels with smooth muscle in the superficial dermis, which may be a kind of malformation, and these lymphatic vessels produce some chemokines that induce intralymphatic aggregation of macrophages.
DOI: 10.1111/cup.12754
PubMed: 27256924
Affiliations:
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Le document en format XML
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Noriki" uniqKey="Fujimoto N" first="Noriki" last="Fujimoto">Noriki Fujimoto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Shiga University of Medical Science, Otsu, Shiga, Japan. noriki@belle.shiga-med.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Shiga University of Medical Science, Otsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Nakanishi, Gen" sort="Nakanishi, Gen" uniqKey="Nakanishi G" first="Gen" last="Nakanishi">Gen Nakanishi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Shiga University of Medical Science, Otsu, Shiga, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Shiga University of Medical Science, Otsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Manabe, Toshiaki" sort="Manabe, Toshiaki" uniqKey="Manabe T" first="Toshiaki" last="Manabe">Toshiaki Manabe</name><affiliation wicri:level="1"><nlm:affiliation>Shiga Medical Center Research for Adults, Research Institute, Moriyama, Shiga, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Shiga Medical Center Research for Adults, Research Institute, Moriyama, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Fujimura, Taku" sort="Fujimura, Taku" uniqKey="Fujimura T" first="Taku" last="Fujimura">Taku Fujimura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi</wicri:regionArea><wicri:noRegion>Miyagi</wicri:noRegion></affiliation></author><author><name sortKey="Tanaka, Toshihiro" sort="Tanaka, Toshihiro" uniqKey="Tanaka T" first="Toshihiro" last="Tanaka">Toshihiro Tanaka</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Shiga University of Medical Science, Otsu, Shiga, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Shiga University of Medical Science, Otsu, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of cutaneous pathology</title><idno type="eISSN">1600-0560</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Chronic Disease</term><term>Dermis (metabolism)</term><term>Dermis (pathology)</term><term>Female</term><term>Histiocytosis (metabolism)</term><term>Histiocytosis (pathology)</term><term>Humans</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Macrophages (metabolism)</term><term>Macrophages (pathology)</term><term>Muscle, Smooth (metabolism)</term><term>Muscle, Smooth (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Derme (anatomopathologie)</term><term>Derme (métabolisme)</term><term>Femelle</term><term>Histiocytose (anatomopathologie)</term><term>Histiocytose (métabolisme)</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Macrophages (anatomopathologie)</term><term>Macrophages (métabolisme)</term><term>Maladie chronique</term><term>Muscles lisses (anatomopathologie)</term><term>Muscles lisses (métabolisme)</term><term>Sujet âgé</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Derme</term><term>Histiocytose</term><term>Lymphoedème</term><term>Macrophages</term><term>Muscles lisses</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dermis</term><term>Histiocytosis</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Macrophages</term><term>Muscle, Smooth</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Derme</term><term>Histiocytose</term><term>Lymphoedème</term><term>Macrophages</term><term>Muscles lisses</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dermis</term><term>Histiocytosis</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Macrophages</term><term>Muscle, Smooth</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Chronic Disease</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Maladie chronique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intralymphatic histiocytosis represents a rare reactive disorder, which is characterized by the accumulation of macrophages within lymphatic vessels and observed predominantly in upper extremities. The infiltration and preferential M2 differentiation of macrophage are observed in chronic lymphedema, and lymphedema is considered a causative factor of intralymphatic histiocytosis. However, what causes accumulation of histiocytes in the lymphatic vessels remains unclear, and investigation regarding the characteristics of the macrophages has not been evaluated. We present a case of intralymphatic histiocytosis, in which immunohistochemical staining for both macrophages and lymphatic vessels was performed to evaluate the nature of macrophages within lymphatic vessels and to determine the causative factor. Aggregated macrophages were shown to be M2 macrophages positive for CD68, CD163 and CD206 but negative for inducible nitric oxide synthase. Thick lymphatic vessels positive for D2-40 and α-SMA in the superficial dermis were observed. We speculate that chronic lymphedema leads to hypertrophy of lymphatic vessels with smooth muscle in the superficial dermis, which may be a kind of malformation, and these lymphatic vessels produce some chemokines that induce intralymphatic aggregation of macrophages.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Fujimoto, Noriki" sort="Fujimoto, Noriki" uniqKey="Fujimoto N" first="Noriki" last="Fujimoto">Noriki Fujimoto</name></noRegion><name sortKey="Fujimura, Taku" sort="Fujimura, Taku" uniqKey="Fujimura T" first="Taku" last="Fujimura">Taku Fujimura</name><name sortKey="Manabe, Toshiaki" sort="Manabe, Toshiaki" uniqKey="Manabe T" first="Toshiaki" last="Manabe">Toshiaki Manabe</name><name sortKey="Nakanishi, Gen" sort="Nakanishi, Gen" uniqKey="Nakanishi G" first="Gen" last="Nakanishi">Gen Nakanishi</name><name sortKey="Tanaka, Toshihiro" sort="Tanaka, Toshihiro" uniqKey="Tanaka T" first="Toshihiro" last="Tanaka">Toshihiro Tanaka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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